Structure of PDB 4yia Chain A Binding Site BS01

Receptor Information
>4yia Chain A (length=337) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LYKMSSINADFAFNLYRRFTVETPDKNIFFSPVSISAALVMLSFGACCST
QTEIVETLGFNLTDTPMVEIQHGFQHLICSLNFPKKELELQIGNALFIGK
HLKPLAKFLNDVKTLYETEVFSTDFSNISAAKQEINSHVEMQTKGKVVGL
IQDLKPNTIMVLVNYIHFKAQWANPFDPSKTEDSSSFLIDKTTTVQVPMM
HQMEQYYHLVDMELNCTVLQMDYSKNALALFVLPKEGQMESVEAAMSSKT
LKKWNRLLQKGWVDLFVPKFSISATYDLGATLLKMGIQHAYSENADFSGL
TEDNGLKLSNAAHKAVLHIGEKGTEAAGAMFLEAIPR
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain4yia Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4yia Structural mechanism of hormone release in thyroxine Binding globulin
Resolution1.58 Å
Binding residue
(original residue number in PDB)		N192 Q220 E222
Binding residue
(residue number reindexed from 1)		N174 Q202 E204
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004867 serine-type endopeptidase inhibitor activity
Cellular Component
GO:0005615 extracellular space

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Molecular Function
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Cellular Component
External links
PDB RCSB:4yia, PDBe:4yia, PDBj:4yia
PDBsum4yia
PubMed
UniProtP05543|THBG_HUMAN Thyroxine-binding globulin (Gene Name=SERPINA7)

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