Structure of PDB 4ydx Chain A Binding Site BS01

Receptor Information
>4ydx Chain A (length=67) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PKHEFSVDMTCGGCAEAVSRVLNKLGGVKYDIDLPNKKVCIESEHSMDTL
LATLKKTGKTVSYLGLE
Ligand information
Ligand IDPT
InChIInChI=1S/Pt/q+2
InChIKeyHRGDZIGMBDGFTC-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Pt++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Pt+2]
FormulaPt
NamePLATINUM (II) ION
ChEMBL
DrugBank
ZINC
PDB chain4ydx Chain A Residue 101 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB4ydx Crystallography and chemistry should always go together: a cautionary tale of protein complexes with cisplatin and carboplatin.
Resolution1.602 Å
Binding residue
(original residue number in PDB)		T11 C12 C15
Binding residue
(residue number reindexed from 1)		T10 C11 C14
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005507 copper ion binding
GO:0005515 protein binding
GO:0016530 metallochaperone activity
GO:0016531 copper chaperone activity
GO:0032767 copper-dependent protein binding
GO:0046872 metal ion binding
GO:1903136 cuprous ion binding
Biological Process
GO:0006825 copper ion transport
GO:0006878 intracellular copper ion homeostasis
GO:0006979 response to oxidative stress
Cellular Component
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4ydx, PDBe:4ydx, PDBj:4ydx
PDBsum4ydx
PubMed26327386
UniProtO00244|ATOX1_HUMAN Copper transport protein ATOX1 (Gene Name=ATOX1)

[Back to BioLiP]