Structure of PDB 4y5w Chain A Binding Site BS01

Receptor Information
>4y5w Chain A (length=478) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KFKTGLRRLQHRVGEIHLLREALQKALAMLLQETTGELEAAKALVLKRIQ
IWKRQQQLAGNGAPFEESLAPLQERCESLVDIYSQLQQEVGAAGGETRAS
LTGRLDEVLRTLVTSCFLVEKQPPQVLKTQTKFQAGVRFLLGLRFLGPAK
PPLVRADMVTEKQARETGEIINNTVPLENSIPGNCCSALFKNLLLKKIKR
CERKGTESVTEEKCAVLFSASFTLGLPIQLQALSLPLVVIVHGNQDNNAK
ATILWDNAFSEMDRVPFVVAERVPWEKMCETLNLKFMAEVGTNRGLLPEH
FLFLAQKIFNDNSLSMEAFQHRSVSWSQFNKEILLGRGFTFWQWFDGVLD
LTKRCLRSYWSDRLIIGFISKQYVTSLLLNEPDGTFLLRFSDSEIGGITI
AHVIRGQDGSPQIENIQPFSAKDLSIRSLGDRIRDLAQLKNLYPKKPKDE
AFRSHYKPEQMGKDGRGYVPATIKMTVE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4y5w Structural basis for DNA recognition by STAT6
Resolution3.104 Å
Binding residue
(original residue number in PDB)		K288 K374 H415
Binding residue
(residue number reindexed from 1)		K132 K204 H242
Binding affinityPDBbind-CN: Kd=79nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:4y5w, PDBe:4y5w, PDBj:4y5w
PDBsum4y5w
PubMed27803324
UniProtP42226|STAT6_HUMAN Signal transducer and activator of transcription 6 (Gene Name=STAT6)

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