Structure of PDB 4y1d Chain A Binding Site BS01

Receptor Information

>4y1d Chain A (length=141) Species: 11676 (Human immunodeficiency virus 1)

SPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAG
RWPVKTVHTDNGSNFTSTTVKAACDWAGIKQEIESMNKELKKIIGQVRDQ
AEHLKTAVQMAVFIHNHKRKGGIGGYSAGERIVDIIATDIQ

Ligand information

>4y1d Chain D (length=6) Species: 32630 (synthetic construct)

KKDNVP

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4y1d HEXAPEPTIDE MIMETICS OF LEDGF IN COMPLEX WITH HIV-1 INTEGRASE
• Resolution: 1.93 Å
• Binding residue (original residue number in PDB): A169 E170 H171 T174
• Binding residue (residue number reindexed from 1): A101 E102 H103 T106

Enzymatic activity

• Enzyme Commision number: 2.7.7.-
  2.7.7.49: RNA-directed DNA polymerase.
  2.7.7.7: DNA-directed DNA polymerase.
  3.1.-.-
  3.1.13.2: exoribonuclease H.
  3.1.26.13: retroviral ribonuclease H.
  3.4.23.16: HIV-1 retropepsin.

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding

Biological Process

• GO:0015074 DNA integration

External links

• PDB: RCSB:4y1d, PDBe:4y1d, PDBj:4y1d
• PDBsum: 4y1d
• UniProt: P12497|POL_HV1N5 Gag-Pol polyprotein (Gene Name=gag-pol)