Structure of PDB 4xz1 Chain A Binding Site BS01

Receptor Information
>4xz1 Chain A (length=254) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVH
DVRFHHFPIERQLNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPC
NRPSGLEPQPGVFDSLRDAMVRDYVRQTWKLEGEALEQAIISQAPQVEKL
IATTAHERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQGTYALSL
IYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKE
ACPN
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4xz1 Modification by covalent reaction or oxidation of cysteine residues in the tandem-SH2 domains of ZAP-70 and Syk can block phosphopeptide binding.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		R17 R37 R41 H57 H58 F59 P60 R170 R190 R192 Y209 H210 Y211 I223 G226 Y238 D244 G245
Binding residue
(residue number reindexed from 1)		R15 R35 R39 H55 H56 F57 P58 R168 R188 R190 Y207 H208 Y209 I221 G224 Y236 D242 G243
Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Gene Ontology
Molecular Function
GO:0004715 non-membrane spanning protein tyrosine kinase activity

View graph for
Molecular Function
External links
PDB RCSB:4xz1, PDBe:4xz1, PDBj:4xz1
PDBsum4xz1
PubMed25287889
UniProtP43403|ZAP70_HUMAN Tyrosine-protein kinase ZAP-70 (Gene Name=ZAP70)

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