Structure of PDB 4xww Chain A Binding Site BS01

Receptor Information

>4xww Chain A (length=545) Species: 1299 (Deinococcus radiodurans)

PAPTLEVIPLGGMGEIGKNITVFRYGDEIVVVDGGLAFPKAHQMGIDLIV
PRIDYLLEHQDKIKGWILTHGHEDHIGGLPYIFARLPRVPVYGLPLTLAL
VREKLSEFGLQDVDLREVTYGDEVRFGQSFVAEFFCMTHSIPDNAGYILK
TPVGDVLHTGDFKIDPDVGTGAGIVSDLERVEQAGKDGVLLLISDSTNAE
RPGHTPSEAEIARNLEEIIKGCRGRVFLTTFASQVYRIQNILDLAHRQGR
RVVMEGRSMIKYAQAAQATGHMNPPEPFLTSEEVGELQDQQVLFVCTGSQ
GQPMAVLGRLAFGTHAKIALRRGDTVILSSNPIPGNEDAVNLIVNRLYEI
GVDVVYPPTYRVHASGHASQEELATILNLTRPKFFLPWHGEPRHQINHAK
LAQTLPRPPKRTLIAKNGDIVNLGPDEFRVSGTVAAGAVYVDGLGVGDVN
DDVLLDRVNLSQEGLLILTAVLHPTPHVEVVARGFARPNRDLELQIRRVA
LEAVEQGLREKKRLEDVRDDMYGAVRRFTRKATGRNPVLIPMIVD

Ligand information

>4xww Chain D (length=7)

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.......

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4xww Structural insights into catalysis and dimerization enhanced exonuclease activity of RNase J
• Resolution: 1.7 Å
• Binding residue (original residue number in PDB): I30 F52 H86 E87 D88 A246 S247 R271 S272 T311 Q316 A319 R323 I347 P348 H377 S379 H381
• Binding residue (residue number reindexed from 1): I16 F38 H72 E73 D74 A232 S233 R257 S258 T297 Q302 A305 R309 I333 P334 H363 S365 H367

Enzymatic activity

• Enzyme Commision number: 3.1.-.-

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0004519 endonuclease activity
• GO:0004521 RNA endonuclease activity
• GO:0004527 exonuclease activity
• GO:0004534 5'-3' RNA exonuclease activity
• GO:0008270 zinc ion binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006364 rRNA processing
• GO:0006396 RNA processing

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:4xww, PDBe:4xww, PDBj:4xww
• PDBsum: 4xww
• PubMed: 25940620
• UniProt: H9CZL7