Structure of PDB 4xvm Chain A Binding Site BS01

Receptor Information
>4xvm Chain A (length=627) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KKHFCDIRHLDDWAKSQLIEMLKQAAALVITVMYTDGSTQLGADQTPVSS
VRGIVVLVKRQACGPVLEGFVSDDPCIYIQIEHSAIWDQEQEAHQQFARN
VLFQTMKCKCPVICFNAKDFVRIVLQFFGNDGSWKHVADFIGLDPRIAAW
LIDPSDATPSFEDLVEKYCEKSITVKVNSTYGNSSRNIVNQNVRENLKTL
YRLTMDLCSKLKDYGLWQLFRTLELPLIPILAVMESHAIQVNKEEMEKTS
ALLGARLKELEQEAHFVAGERFLITSNNQLREILFGKLKLHLKYPSTSEA
VLNALRDLHPLPKIILEYRQVHKIKSTFVDGLLACMKKGSISSTWNQTGT
VTGRLSAKHPNIQGISKHPIQITTPKKILTISPRAMFVSSKGHTFLAADF
SQIELRILTHLSGDPELLKLDDVFSTLTSQWKDVPVEQVTHADREQTKKV
VYAVVYGAGKERLAACVPIQEAAQFLESFLQKYKKIKDFARAAIAQCHQT
GCVVSIMGRRRPLPRIHAHDQQLRAQAERQAVNFVVQGSAADLCKLAMIH
VFTAVAASHTLTARLVAQIHDELLFEVEDPQIPECAALVRRTMESLEQVQ
ALELQLQVPLKVSLSAGRSWGHLVPLQ
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4xvm How a homolog of high-fidelity replicases conducts mutagenic DNA synthesis.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		H539 S543 T544 T567 V568 A574 H576 N578 A683 Y686 A688 G689 R692 R743 R761 Q762 N765 Q769
Binding residue
(residue number reindexed from 1)		H322 S326 T327 T350 V351 A357 H359 N361 A453 Y456 A458 G459 R462 R511 R529 Q530 N533 Q537
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication

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Molecular Function
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Biological Process
External links
PDB RCSB:4xvm, PDBe:4xvm, PDBj:4xvm
PDBsum4xvm
PubMed25775266
UniProtQ7Z5Q5|DPOLN_HUMAN DNA polymerase nu (Gene Name=POLN)

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