Structure of PDB 4xvi Chain A Binding Site BS01

Receptor Information
>4xvi Chain A (length=647) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KKHFCDIRHLDDWAKSQLIEMLKQAAALVITVMYTDGSTQLGADQTPVSS
VRGIVVLVKRQAEGCGPVLEGFVSDDPCIYIQIEHSAIWDQEQEAHQQFA
RNVLFQTMKCKCPVICFNAKDFVRIVLQFFGNDGSWKHVADFIGLDPRIA
AWLIDPSDATPSFEDLVEKYCEKSITVKVNSTYGNSSRNIVNQNVRENLK
TLYRLTMDLCSKLKDYGLWQLFRTLELPLIPILAVMESHAIQVNKEEMEK
TSALLGARLKELEQEAHFVAGERFLITSNNQLREILFGKLKLHLLSQRNS
LPRTGLQKYPSTSEAVLNALRDLHPLPKIILEYRQVHKIKSTFVDGLLAC
MKKGSISSTWNQTGTVTGRLSAKHPNIQGISKHPIQITTPKKILTISPRA
MFVSSKGHTFLAADFSQIELRILTHLSGDPELLKLFQRDDVFSTLTSQWK
DVPVEQVTHADREQTKKVVYAVVYGAGKERLAACLGVPIQEAAQFLESFL
QKYKKIKDFARAAIAQCHQTGCVVSIMGRRRPLPRIHAHDQQLRAQAERQ
AVNFVVQGSAADLCKLAMIHVFTAVAASHTLTARLVAQIHDELLFEVEDP
QIPECAALVRRTMESLEQVQALELQLQVPLKVSLSAGRSWGHLVPLQ
Ligand information
Receptor-Ligand Complex Structure
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PDB4xvi How a homolog of high-fidelity replicases conducts mutagenic DNA synthesis.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		T514 E516 R536 K540 R571 Q580 S583 Y686 D803
Binding residue
(residue number reindexed from 1)		T312 E314 R334 K338 R369 Q378 S381 Y474 D591
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication

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Molecular Function
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Biological Process
External links
PDB RCSB:4xvi, PDBe:4xvi, PDBj:4xvi
PDBsum4xvi
PubMed25775266
UniProtQ7Z5Q5|DPOLN_HUMAN DNA polymerase nu (Gene Name=POLN)

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