Structure of PDB 4xrh Chain A Binding Site BS01

Receptor Information

>4xrh Chain A (length=243) Species: 9606 (Homo sapiens)

PVLELFSNIWGAGTKTAQMWYQQGFRSLEDIRSQASLTTQQAIGLKHYSD
FLERMPREEATEIEQTVQKAAQAFNSGLLCVACGSYRRGKATCGDVDVLI
THPDGRSHRGIFSRLLDSLRQEGFLTDDLVSQEENGQQQKYLGVCRLPGP
GRRHRRLDIIVVPYSEFACALLYFTGSAHFNRSMRALAKTKGMSLSEHAL
STAVVRNTHGCKVGPGRVLPTPTEKDVFRLLGLPYREPAERDW

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 4xrh Chain A Residue 601

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4xrh Structural Mechanism for the Fidelity Modulation of DNA Polymerase lambda
• Resolution: 3.0 Å
• Binding residue (original residue number in PDB): D427 D429
• Binding residue (residue number reindexed from 1): D95 D97
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): D427 D429 D490
• Catalytic site (residue number reindexed from 1): D95 D97 D158
• Enzyme Commision number: 2.7.7.7: DNA-directed DNA polymerase.
  4.2.99.-

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003887 DNA-directed DNA polymerase activity
• GO:0016779 nucleotidyltransferase activity
• GO:0034061 DNA polymerase activity

Biological Process

• GO:0006281 DNA repair

External links

• PDB: RCSB:4xrh, PDBe:4xrh, PDBj:4xrh
• PDBsum: 4xrh
• PubMed: 26836966
• UniProt: Q9UGP5|DPOLL_HUMAN DNA polymerase lambda (Gene Name=POLL)