Structure of PDB 4xpz Chain A Binding Site BS01

Receptor Information

>4xpz Chain A (length=364) Species: 284812 (Schizosaccharomyces pombe 972h-)

RLESENVKRLRQEKRLSLIVDLDQTIIHATVDPTVGEWMSDPGNVNYDVL
RDVRSFNLQEGPSGYTSCYYIKFRPGLAQFLQKISELYELHIYTMGTKAY
AKEVAKIIDPTGKLFQDRVLSADDSGSLAQKSLRRLFPCDTSMVVVIDDR
GDVWDWNPNLIKVVPYEFFVGIGDINSNFLGSNREALEEQNKERVTALEL
QKSERPLAKQQNALLEDPSHTLLHNRDHELERLEKVLKDIHAVYYEEEND
ISSRSGNHKHANVGLIIPKMKQKVLKGCRLLFSGVIPLGVDVLSSDIAKW
AMSFGAEVVLDFSVPPTHLIAAKIRTEKVKKAVSMGNIKVVKLNWLTESL
SQWKRLPESDYLLY

Ligand information

• Ligand ID: AF3
• InChI: InChI=1S/Al.3FH/h;3*1H/q+3;;;/p-3
• InChIKey: KLZUFWVZNOTSEM-UHFFFAOYSA-K
• SMILES:
  ACDLabs 10.04
  CACTVS 3.341
  OpenEye OEToolkits 1.5.0: F[Al](F)F
• Formula: Al F3
• Name: ALUMINUM FLUORIDE
• PDB chain: 4xpz Chain A Residue 601

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4xpz Genetic and structural analysis of the essential fission yeast RNA polymerase II CTD phosphatase Fcp1.
• Resolution: 1.45 Å
• Binding residue (original residue number in PDB): D170 L171 D172 T243 M244 K280
• Binding residue (residue number reindexed from 1): D21 L22 D23 T94 M95 K131
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.1.3.16: protein-serine/threonine phosphatase.

Gene Ontology

Molecular Function

• GO:0004721 phosphoprotein phosphatase activity
• GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity

Cellular Component

• GO:0005634 nucleus

External links

• PDB: RCSB:4xpz, PDBe:4xpz, PDBj:4xpz
• PDBsum: 4xpz
• PubMed: 25883047
• UniProt: Q9P376|FCP1_SCHPO RNA polymerase II subunit A C-terminal domain phosphatase (Gene Name=fcp1)