Structure of PDB 4xm5 Chain A Binding Site BS01

Receptor Information
>4xm5 Chain A (length=267) Species: 5478 (Nakaseomyces glabratus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EEFQQIPDFYGCYLLQSISKRQSFYIGSTPNPVRRLRQHNGSLSRRDGTR
PWEMVAIVYGFPSRIAALQFQHAWQHGYQTRYVKTRKGGRSIHHKLAMIT
SLLKNEYFRYMDLTLHFFNQKVEEIWKNDKFNVSQNNYTVSLSQDALTEI
NNDTIDDIMDVNEKNMELVQNLYSTTLAEKTKTLLLYKEKIDTGINTCQF
CNKIINLFAFCRDTSCTFVSHLACAYRYFMSNEDTIIPQSPKCPKCYTLL
KWCDVIYYSIKLNKDNT
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain4xm5 Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4xm5 Structural and Mechanistic Analysis of the Slx1-Slx4 Endonuclease.
Resolution2.34 Å
Binding residue
(original residue number in PDB)		C219 C222 H252 C255
Binding residue
(residue number reindexed from 1)		C198 C201 H221 C224
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0004519 endonuclease activity
GO:0004520 DNA endonuclease activity
GO:0008821 crossover junction DNA endonuclease activity
GO:0017108 5'-flap endonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0000724 double-strand break repair via homologous recombination
GO:0006261 DNA-templated DNA replication
GO:0006281 DNA repair
GO:0006310 DNA recombination
Cellular Component
GO:0005634 nucleus
GO:0033557 Slx1-Slx4 complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4xm5, PDBe:4xm5, PDBj:4xm5
PDBsum4xm5
PubMed25753413
UniProtQ6FML9|SLX1_CANGA Structure-specific endonuclease subunit SLX1 (Gene Name=SLX1)

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