Structure of PDB 4xif Chain A Binding Site BS01

Receptor Information

>4xif Chain A (length=702) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVL
QQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRA
IQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNLAH
CLQIVCDWTDYDERMKKLVSIVADQLEKNRLPSVHPHHSMLYPLSHGFRK
AIAERHGNLCLDKINVLHKPPYEHPKDLKLSDGRLRVGYVSSDFGNHPTS
HLMQSIPGMHNPDKFEVFCYALSPDDGTNFRVKVMAEANHFIDLSQIPCN
GKAADRIHQDGIHILVNMNGYTKGARNELFALRPAPIQAMWLGYPGTSGA
LFMDYIITDQETSPAEVAEQYSEKLAYMPHTFFIGDHANMFPHLKKKAVI
DFKHIYDNRIVLNGIDLKAFLDSLPDVKIVKMKCALNMPVIPMNTIAEAV
IEMINRGQIQITINGFSISNGLATTQINNKAATGEEVPRTIIVTTRSQYG
LPEDAIVYCNFNQLYKIDPSTLQMWANILKRVPNSVLWLLRFPAVGEPNI
QQYAQNMGLPQNRIIFSPVAPKEEHVRRGQLADVCLDTPLCNGHTTGMDV
LWAGTPMVTMPGETLASRVAASQLTCLGCLELIAKNRQEYEDIAVKLGTD
LEYLKKVRGKVWKQRISSPLFNTKQYTMELERLYLQMWEHYAAGNKPDHM
IK

Ligand information

>4xif Chain E (length=11) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

GPVFTSRSAAG

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4xif The active site of O-GlcNAc transferase imposes constraints on substrate sequence.
Resolution	3.2 Å
Binding residue (original residue number in PDB)	H496 N557 P559 Y632 T633 K634 P897
Binding residue (residue number reindexed from 1)	H185 N246 P248 Y321 T322 K323 P571

Enzymatic activity

Enzyme Commision number

2.4.1.255: protein O-GlcNAc transferase.

External links

PDB	RCSB:4xif, PDBe:4xif, PDBj:4xif
PDBsum	4xif
PubMed	26237509
UniProt	O15294\|OGT1_HUMAN UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (Gene Name=OGT)

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