Structure of PDB 4xi7 Chain A Binding Site BS01

Receptor Information
>4xi7 Chain A (length=362) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SRVMVEGVGARVVRGPDWKWGKQDGGEGHVGTVRSFESPEEVVVVWDNGT
AANYRCSGAYDLRILDSAPTGIKHDGTMCDTCRQQPIIGIRWKCAECTNY
DLCTVCYHGDKHHLRHRFYRITTPGSERVLLESRRKSKKITARGIFAGAR
VVRGVDWQWEDQDGGNGRRGKVTEIQDWSASSPHSAAYVLWDNGAKNLYR
VGFEGMSDLKCVQDAKGGSFYRDHCPVLGVNIDLDLEIVQSLQHGHGGWT
DGMFETLTTTGTVCGIDEDHDIVVQYPSGNRWTFNPAVLTKASQFQVGDL
VQVCYDLERIKLLQRGHGEWAEAMLPTLGKVGRVQQIYSDSDLKVEVCGT
SWTYNPAAVSKV
Ligand information
Receptor-Ligand Complex Structure
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PDB4xi7 A tail of two sites: a bipartite mechanism for recognition of notch ligands by mind bomb e3 ligases.
Resolution2.051 Å
Binding residue
(original residue number in PDB)		W26 Q29 E47 A57 A58 N59 Y60
Binding residue
(residue number reindexed from 1)		W20 Q23 E41 A51 A52 N53 Y54
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0016567 protein ubiquitination

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Molecular Function
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Biological Process
External links
PDB RCSB:4xi7, PDBe:4xi7, PDBj:4xi7
PDBsum4xi7
PubMed25747658
UniProtQ86YT6|MIB1_HUMAN E3 ubiquitin-protein ligase MIB1 (Gene Name=MIB1)

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