Structure of PDB 4xhz Chain A Binding Site BS01

Receptor Information

>4xhz Chain A (length=333) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFF
ALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI
VKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRY
RVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV
MSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQ
SIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVV
LANLRVPSKSNTAKVYIEIQDENNHPPVFLEHH

Ligand information

Ligand ID

InChI

InChI=1S/Ca/q+2

InChIKey

BHPQYMZQTOCNFJ-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Ca++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Ca+2]

Formula

Name

CALCIUM ION

PDB chain

4xhz Chain A Residue 2001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4xhz An elastic element in the protocadherin-15 tip link of the inner ear.
Resolution	2.803 Å
Binding residue (original residue number in PDB)	N899 Y901 D931 D933 A939 D989
Binding residue (residue number reindexed from 1)	N105 Y107 D137 D139 A145 D195
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0005509	calcium ion binding

	Biological Process
GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
GO:0098609	cell-cell adhesion

	Cellular Component
GO:0016020	membrane

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Cellular Component

External links

PDB	RCSB:4xhz, PDBe:4xhz, PDBj:4xhz
PDBsum	4xhz
PubMed	27857071
UniProt	Q96QU1\|PCD15_HUMAN Protocadherin-15 (Gene Name=PCDH15)

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