Structure of PDB 4xgr Chain A Binding Site BS01

Receptor Information
>4xgr Chain A (length=128) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MMVIDTSALVAMLSDEPDAERFEAAVEADHIRLMSTASYLETALVIEARF
GEPGGRELDLWLHRAAVDLVAVHADQADAARAAYRTYGKAGLNYGDCFSY
GLAKISGQPLLFKGEDFQHTDIATVALP
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain4xgr Chain A Residue 201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB4xgr Structural and functional studies of the Mycobacterium tuberculosis VapBC30 toxin-antitoxin system: implications for the design of novel antimicrobial peptides
Resolution2.7 Å
Binding residue
(original residue number in PDB)		D4 D99
Binding residue
(residue number reindexed from 1)		D5 D96
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004518 nuclease activity
GO:0004540 RNA nuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0045926 negative regulation of growth

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4xgr, PDBe:4xgr, PDBj:4xgr
PDBsum4xgr
PubMed26150422
UniProtP9WF77|VPC30_MYCTU Ribonuclease VapC30 (Gene Name=vapC30)

[Back to BioLiP]