Structure of PDB 4xgl Chain A Binding Site BS01

Receptor Information
>4xgl Chain A (length=342) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TLEPRGYSLLIRGLIHSDRWREALLLLEDIKKVITPSKKNYNDCIQGALL
HQDVNTAWNLYQELLGHDIVPMLETLKAFFDFGKDIKDDNYSNKLLDILS
YLRNNQLYPGESFAHSIKTWFESVPGKQWKGQFTTVRKSGQCSGCGKTIE
SIQLSPEEYECLKGKIMRDVITTPQELKRFENFIKSRPPFDVVIDGLNVA
KMESQLLLNVVSQLAKRNLRLLVLGRKHMLRDEMEEVQKQASCFFADDID
DPFLLYATLHSGNHCRFITRDLMDAKTQRLFFKWQQGHQLAIVNSKLTFQ
RILSYDTVVQTTGDSWHIPYDEDLVERCSCEVPTKWLCLHQK
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain4xgl Chain A Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4xgl Structure of the nuclease subunit of human mitochondrial RNase P.
Resolution1.8 Å
Binding residue
(original residue number in PDB)		C348 C351 H557 C578
Binding residue
(residue number reindexed from 1)		C142 C145 H317 C338
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.26.5: ribonuclease P.
Gene Ontology
Biological Process
GO:0008033 tRNA processing
Cellular Component
GO:0005739 mitochondrion

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Biological Process
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Cellular Component
External links
PDB RCSB:4xgl, PDBe:4xgl, PDBj:4xgl
PDBsum4xgl
PubMed25953853
UniProtO15091|MRPP3_HUMAN Mitochondrial ribonuclease P catalytic subunit (Gene Name=PRORP)

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