Structure of PDB 4xev Chain A Binding Site BS01

Receptor Information
>4xev Chain A (length=148) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NLDRTDDLVYLNVMELVRAVLELKNELSQLPPEGYVVVVKNVGLTLRKLI
GSVDDLLPSLPSSSRTEIEGTQKLLNKDLAELINKMRLAQQNAVTSLSEE
AKRQMLTASHTLAVDAKNLLDAVDQAKVLANLAHGGEELDALLEELER
Ligand information
Receptor-Ligand Complex Structure
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PDB4xev Structural Basis for the Interaction between Pyk2-FAT Domain and Leupaxin LD Repeats.
Resolution2.0073 Å
Binding residue
(original residue number in PDB)		V907 K911 G914 L917 R918 D925 N947 M957 R958
Binding residue
(residue number reindexed from 1)		V36 K40 G43 L46 R47 D54 N76 M86 R87
Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Gene Ontology
Molecular Function
GO:0004713 protein tyrosine kinase activity
Biological Process
GO:0006468 protein phosphorylation
GO:0007172 signal complex assembly
Cellular Component
GO:0005925 focal adhesion

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4xev, PDBe:4xev, PDBj:4xev
PDBsum4xev
PubMed26866573
UniProtQ14289|FAK2_HUMAN Protein-tyrosine kinase 2-beta (Gene Name=PTK2B)

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