Structure of PDB 4xes Chain A Binding Site BS01

Receptor Information
>4xes Chain A (length=471) Species: 10116,10665 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AGPNSDLDVNTDIYSKVLVTAIYLALFVVGTVGNSVTLFTLARKKSLQSL
QSTVHYHLGSLALSDLLILLLAMPVELYNFIWVHHPWAFGDAGCRGYYFL
RDACTYATALNVASLSVARYLAICHPFKAKTLMSRSRTKKFISAIWLASA
LLAIPMLFTMGLQNRSADGTHPGGLVCTPIVDTATVKVVIQVNTFMSFLF
PMLVISILNTVIANKLTVMVPGRVQALRHGVLVLRAVVIAFVVCWLPYHV
RRLMFCYISDEQWTTFLFDFYHYFYMLTNALFYASSAINPILYNLVSANF
RQVFLSTNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKS
ELDKAIGRNTNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAV
RRAALINMVFQMGETGVAGFTNSLRMLNNKRWDEAAVNLAKSRWYNQTPN
RAKRVITTFRTGTWDAYGSGS
Ligand information
Receptor-Ligand Complex Structure
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PDB4xes Structural prerequisites for G-protein activation by the neurotensin receptor.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		D54 L55 F128 H132 Y146 V224 T226 R327 F331 I334 W339 F344 Y347
Binding residue
(residue number reindexed from 1)		D6 L7 F80 H84 Y98 V176 T178 R251 F255 I258 W263 F268 Y271
Enzymatic activity
Catalytic site (original residue number in PDB) E1011 D1020
Catalytic site (residue number reindexed from 1) E317 D326
Enzyme Commision number 3.2.1.17: lysozyme.
Gene Ontology
Molecular Function
GO:0003796 lysozyme activity
GO:0004930 G protein-coupled receptor activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0009253 peptidoglycan catabolic process
GO:0016998 cell wall macromolecule catabolic process
GO:0031640 killing of cells of another organism
GO:0042742 defense response to bacterium
GO:0044659 viral release from host cell by cytolysis
Cellular Component
GO:0016020 membrane
GO:0030430 host cell cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4xes, PDBe:4xes, PDBj:4xes
PDBsum4xes
PubMed26205105
UniProtP00720|ENLYS_BPT4 Endolysin (Gene Name=E);
P20789|NTR1_RAT Neurotensin receptor type 1 (Gene Name=Ntsr1)

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