Structure of PDB 4x9w Chain A Binding Site BS01
Receptor Information
>4x9w Chain A (length=226) Species:
9606
(Homo sapiens) [
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CHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKY
GLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNS
LMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAI
ILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYG
CCKELASRLRYARTMVDKLLSSRSAS
Ligand information
>4x9w Chain B (length=4) Species:
32630
(synthetic construct) [
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LcST
Receptor-Ligand Complex Structure
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PDB
4x9w
Neighbor-directed histidine N ( tau )-alkylation: A route to imidazolium-containing phosphopeptide macrocycles.
Resolution
1.798 Å
Binding residue
(original residue number in PDB)
K413 W414 V415 D416 Y417 L478 Y481 Y485 L490 R516 H538 K540
Binding residue
(residue number reindexed from 1)
K42 W43 V44 D45 Y46 L107 Y110 Y114 L119 R145 H167 K169
Enzymatic activity
Enzyme Commision number
2.7.11.21
: polo kinase.
External links
PDB
RCSB:4x9w
,
PDBe:4x9w
,
PDBj:4x9w
PDBsum
4x9w
PubMed
26152807
UniProt
P53350
|PLK1_HUMAN Serine/threonine-protein kinase PLK1 (Gene Name=PLK1)
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