Structure of PDB 4x9v Chain A Binding Site BS01
Receptor Information
>4x9v Chain A (length=217) Species:
9606
(Homo sapiens) [
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CHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKY
GLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNS
LMKKITLLKYFRNYMSEHLLKAGANITARLPYLRTWFRTRSAIILHLSNG
SVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELAS
RLRYARTMVDKLLSSRS
Ligand information
>4x9v Chain B (length=5) Species:
32630
(synthetic construct) [
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PLHST
Receptor-Ligand Complex Structure
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PDB
4x9v
Neighbor-directed histidine N ( tau )-alkylation: A route to imidazolium-containing phosphopeptide macrocycles.
Resolution
1.429 Å
Binding residue
(original residue number in PDB)
K413 W414 V415 D416 Y417 L478 Y481 Y485 L490 R516 F535 H538 K540
Binding residue
(residue number reindexed from 1)
K42 W43 V44 D45 Y46 L107 Y110 Y114 L119 R138 F157 H160 K162
Enzymatic activity
Enzyme Commision number
2.7.11.21
: polo kinase.
External links
PDB
RCSB:4x9v
,
PDBe:4x9v
,
PDBj:4x9v
PDBsum
4x9v
PubMed
26152807
UniProt
P53350
|PLK1_HUMAN Serine/threonine-protein kinase PLK1 (Gene Name=PLK1)
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