Structure of PDB 4x6n Chain A Binding Site BS01

Receptor Information
>4x6n Chain A (length=238) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVE
SPKILRVYSGILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLE
TTVGYGDSQRPICLPSKGDRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKI
PLVTNEECQKRYRGHKITHKMICAGYREGGKDACKGDSGGPLSCKHNEVW
HLVGITSWGEGCAQRERPGVYTNVVEYVDWILEKTQAV
Ligand information
Receptor-Ligand Complex Structure
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PDB4x6n Structure-based design of inhibitors of coagulation factor XIa with novel P1 moieties.
Resolution2.1 Å
Binding residue
(original residue number in PDB)		C122 L239 T242 Q243
Binding residue
(residue number reindexed from 1)		C113 L232 T235 Q236
Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 K192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H44 D93 K185 G186 D187 S188 G189
Enzyme Commision number 3.4.21.27: coagulation factor XIa.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:4x6n, PDBe:4x6n, PDBj:4x6n
PDBsum4x6n
PubMed25728130
UniProtP03951|FA11_HUMAN Coagulation factor XI (Gene Name=F11)

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