Structure of PDB 4x5v Chain A Binding Site BS01

Receptor Information
>4x5v Chain A (length=317) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NHNLHITEKLEVLAKAYSVQGDKWRALGYAKAINALKYQEACSIPGIGKR
MAEKIIEILESGHLRKLDHISESVPVLELFSNIWGAGTKTAQMWYQQGFR
SLEDIRSQASLTTQQAIGLKHYSDFLERMPREEATEIEQTVQKAAQAFNS
GLLCVACGSYRRGKATCGDVDVLITHPDGRSHRGIFSRLLDSLRQEGFLT
DDLVSQEENGQQQKYLGVCRLPGPGRRHRRLDIIVVPYSEFACALLYFTG
SAHFNRSMRALAKTKGMSLSEHALSTAVVRNTHGCKVGPGRVLPTPTEKD
VFRLLGLPYREPAERDW
Ligand information
Receptor-Ligand Complex Structure
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PDB4x5v Nucleotide binding interactions modulate dNTP selectivity and facilitate 8-oxo-dGTP incorporation by DNA polymerase lambda.
Resolution2.15 Å
Binding residue
(original residue number in PDB)		W274 R275 G278 Y279 P303 G304 G306 R308 M309 K312
Binding residue
(residue number reindexed from 1)		W24 R25 G28 Y29 P45 G46 G48 R50 M51 K54
Enzymatic activity
Catalytic site (original residue number in PDB) D427 D429 D490
Catalytic site (residue number reindexed from 1) D169 D171 D232
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
4.2.99.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034061 DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:4x5v, PDBe:4x5v, PDBj:4x5v
PDBsum4x5v
PubMed26220180
UniProtQ9UGP5|DPOLL_HUMAN DNA polymerase lambda (Gene Name=POLL)

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