Structure of PDB 4x4u Chain A Binding Site BS01

Receptor Information
>4x4u Chain A (length=435) Species: 224325 (Archaeoglobus fulgidus DSM 4304) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKVEEILEKALELVIPDEEEVRKGREAEEELRRRLDELGVEYVFVGSYAR
NTWLKGSLEIDVFLLFPEEFSKEELRERGLEIGKAVLDSYEIRYHPYVHG
VVKGVEVDVVPCYKLKEPKNIKSAVDRTPFHHKWLEGRIKGKENEVRLLK
GFLKANGIYGAEYKVRGFSGYLCELLIVFYGSFLETVKNARRWTRRTVID
VAKGEVRKGEEFFVVDPVDEKRNVAANLSLDNLARFVHLCREFMEAPSLG
FFKPKHPLEIEPERLRKIVEERGTAVFAVKFRKPDIVDDNLYPQLERASR
KIFEFLERENFMPLRSAFKASEEFCYLLFECQIKEISRVFRRMGPQFEDE
RNVKKFLSRNRAFRPFIENGRWWAFEMRKFTTPEEGVRSYASTHWHTLGK
NVGESIREYFEIISGEKLFKEPVTAELCEMMGVKD
Ligand information
>4x4u Chain B (length=31) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggcgcugcgggguucgaguccccgugccacc
<<<<...<<<<<.......>>>>>>>>>...
Receptor-Ligand Complex Structure
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PDB4x4u On-Enzyme Refolding Permits Small RNA and tRNA Surveillance by the CCA-Adding Enzyme.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		H97 Y99 V112 A126 T130 A163 Y165 A228 N229 D291 N292 P295 Q296 R299 R302 K303 M345 G346 P347 N354 K357 F358 H398 T399 G401 K402
Binding residue
(residue number reindexed from 1)		H95 Y97 V110 A124 T128 A161 Y163 A226 N227 D289 N290 P293 Q294 R297 R300 K301 M343 G344 P345 N352 K355 F356 H396 T397 G399 K400
Enzymatic activity
Enzyme Commision number 2.7.7.72: CCA tRNA nucleotidyltransferase.
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0000287 magnesium ion binding
GO:0003723 RNA binding
GO:0004810 CCA tRNA nucleotidyltransferase activity
GO:0005524 ATP binding
GO:0016779 nucleotidyltransferase activity
GO:0046872 metal ion binding
GO:0160016 CCACCA tRNA nucleotidyltransferase activity
Biological Process
GO:0001680 tRNA 3'-terminal CCA addition
GO:0008033 tRNA processing
GO:0031123 RNA 3'-end processing
GO:0042245 RNA repair
GO:0106354 tRNA surveillance

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Molecular Function
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Biological Process
External links
PDB RCSB:4x4u, PDBe:4x4u, PDBj:4x4u
PDBsum4x4u
PubMed25640237
UniProtO28126|CCA_ARCFU CCA-adding enzyme (Gene Name=cca)

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