Structure of PDB 4wzq Chain A Binding Site BS01

Receptor Information
>4wzq Chain A (length=476) Species: 12110 (Foot-and-mouth disease virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GLIVDTRDVEERVHVMRKTELAPTVAHGVFNPEFGPAALSNKDPRLNEGV
VLDEVIFSKHKGDTKMSAEDKALFRRCAADYASRLHSVLGTANAPLSIYE
AIKGVDGLDAMEPDTAPGLPWALQGKRRGALIDFENGTVGPEVEAALKLM
EKREYKFACQTFLKDEIRPMEKVRAGKTRIVDVLPVEHILYTRMMIGRFC
AQMHSNNGPQIGSAVGCNPDVDWQRFGTHFAQYRNVWDVDYSAFDANHCS
DAMNIMFEEVFRTEFGFHPNAEWILKTLVNTEHAYENKRITVEGGMPSGC
SATSIINTILNNIYVLYALRRHYEGVELDTYTMISYGDDIVVASDYDLDF
EALKPHFKSLGQTITPADKSDKGFVLGHSITDVTFLKRHFHMDYGTGFYK
PVMASKTLEAILSFARRGTIQEKLISVAGLAVHSGPDEYRRLFEPFQGLF
EIPSYRSLYLRWVNAVCGDAAALEHH
Ligand information
Receptor-Ligand Complex Structure
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PDB4wzq Multifunctionality of a picornavirus polymerase domain: nuclear localization signal and nucleotide recognition.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		E20 L108 D109 R128 V181 V183 R193 H204 G216 C217 N218 S298 G299 C300 S301 S304 Y336
Binding residue
(residue number reindexed from 1)		E20 L108 D109 R128 V181 V183 R193 H204 G216 C217 N218 S298 G299 C300 S301 S304 Y336
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.28: picornain 3C.
3.4.22.46: L-peptidase.
3.6.1.15: nucleoside-triphosphate phosphatase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:4wzq, PDBe:4wzq, PDBj:4wzq
PDBsum4wzq
PubMed25903341
UniProtP03311|POLG_FMDVS Genome polyprotein

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