Structure of PDB 4wzm Chain A Binding Site BS01

Receptor Information

>4wzm Chain A (length=475) Species: 12120 (Foot-and-mouth disease virus (strain C1-Santa Pau))

GLIVDTRDVEERVHVMRETKLAPTVAHGVFNPEFGPAALSNKDPRLNEGV
VLDEVIFSKHKGDTKMSAEDKALFRRCAADYASRLHSVLGTANAPLSIYE
AIKGVDGLDAMEPDTAPGLPWALQGKRRGALIDFENGTVGPEVEAALKLM
EKREYKFACQTFLKDEIRPMEKVRAGKTRIVDVLPVEHILYTRMMIGRFC
AQMHSNNGPQIGSAVGCNPDVDWQRFGTHFAQYRNVWDVDYSAFDANHCS
DAMNIMFEEVFRTEFGFHPNAEWILKTLVNTEHAYENKRITVEGGMPSGC
SATSIINTILNNIYVLYALRRHYEGVELDTYTMISYGDDIVVASDYDLDF
EALKPHFKSLGQTITPADKSDKGFVLGHSITDVTFLKRHFHMDYGTGFYK
PVMASKTLEAILSFARRGTIQEKLISVAGLAVHSGPDEYRRLFEPFQGLF
EIPSYRSLYLRWVNAVCGDAAAALE

Ligand information

>4wzm Chain B (length=8)

augggccc

........

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4wzm Multifunctionality of a picornavirus polymerase domain: nuclear localization signal and nucleotide recognition.
• Resolution: 2.52 Å
• Binding residue (original residue number in PDB): M16 E18 K20 L108 D109 T115 A116 R128 F162 V181 V183 R193 H204 G216 C217 N218 S298 G299 C300 S301 Y336
• Binding residue (residue number reindexed from 1): M16 E18 K20 L108 D109 T115 A116 R128 F162 V181 V183 R193 H204 G216 C217 N218 S298 G299 C300 S301 Y336

Enzymatic activity

• Enzyme Commision number: 2.7.7.48: RNA-directed RNA polymerase.
  3.4.22.28: picornain 3C.
  3.4.22.46: L-peptidase.
  3.6.1.15: nucleoside-triphosphate phosphatase.

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003968 RNA-dependent RNA polymerase activity

Biological Process

• GO:0006351 DNA-templated transcription
• GO:0039694 viral RNA genome replication

External links

• PDB: RCSB:4wzm, PDBe:4wzm, PDBj:4wzm
• PDBsum: 4wzm
• PubMed: 25903341
• UniProt: P03311|POLG_FMDVS Genome polyprotein