Structure of PDB 4wvj Chain A Binding Site BS01

Receptor Information
>4wvj Chain A (length=515) Species: 83333,93062 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LVIWINGDKGYNGLAQVGKKFEKDTGIKVTVEHPYKLEEKFPQVAATGPD
IIFWAHDRFGGYACSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPI
AVEALSLIYNKDLLPNPPKTWEEIPALDGELKAKGKSALMFNLQEPYFTW
PLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADT
DYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPF
VGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYE
EELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVD
EALKDAQTNAGAIVTPYTIKGESMDPTLKDGERVAVNIVGYKTGLEKGNV
VVFHANKNDDYVKRVIGVPGDKVEYKNDTLYVNGKKQDEPYLNYNLKHKQ
GDYITGTFQVKDLPNANPKSNVIPKGKYLVLGDNREVSKDSRAFGLIDED
QIVGKVSFRFWSHPQ
Ligand information
>4wvj Chain D (length=14) Species: 1280 (Staphylococcus aureus) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
GGGGGAPTAKAPSK
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB4wvj Peptide binding to a bacterial signal peptidase visualized by peptide tethering and carrier-driven crystallization.
Resolution1.95 Å
Binding residue
(original residue number in PDB)		C78 Y105 P380 Y381 T382 I383 K384 G385 S387 D424 D425 Y426 V427 K428 V502 K504
Binding residue
(residue number reindexed from 1)		C64 Y91 P366 Y367 T368 I369 K370 G371 S373 D409 D410 Y411 V412 K413 V487 K489
Enzymatic activity
Catalytic site (original residue number in PDB) G385 S387 K428 S503
Catalytic site (residue number reindexed from 1) G371 S373 K413 S488
Enzyme Commision number 3.4.21.89: signal peptidase I.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
GO:0008236 serine-type peptidase activity
GO:0015144 carbohydrate transmembrane transporter activity
GO:1901982 maltose binding
Biological Process
GO:0006465 signal peptide processing
GO:0006508 proteolysis
GO:0006974 DNA damage response
GO:0008643 carbohydrate transport
GO:0015768 maltose transport
GO:0034219 carbohydrate transmembrane transport
GO:0034289 detection of maltose stimulus
GO:0042956 maltodextrin transmembrane transport
GO:0055085 transmembrane transport
GO:0060326 cell chemotaxis
Cellular Component
GO:0016020 membrane
GO:0030288 outer membrane-bounded periplasmic space
GO:0042597 periplasmic space
GO:0043190 ATP-binding cassette (ABC) transporter complex
GO:0055052 ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
GO:1990060 maltose transport complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4wvj, PDBe:4wvj, PDBj:4wvj
PDBsum4wvj
PubMed26870377
UniProtP0AEX9|MALE_ECOLI Maltose/maltodextrin-binding periplasmic protein (Gene Name=malE);
Q5HHB9

[Back to BioLiP]