Structure of PDB 4wv6 Chain A Binding Site BS01

Receptor Information
>4wv6 Chain A (length=426) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLI
PKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLL
ASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSL
ACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADT
CWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIV
TGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQ
QVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGI
IEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLD
KIEALQNHENESVYKASLSLIEKYFS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4wv6 Cytoplasmic TAF2-TAF8-TAF10 complex provides evidence for nuclear holo-TFIID assembly from preformed submodules.
Resolution1.75 Å
Binding residue
(original residue number in PDB)		K102 S105 W142 N146 S149 G150 T155 Q181 W184 N188 G191 D192 W231 R238
Binding residue
(residue number reindexed from 1)		K31 S34 W71 N75 S78 G79 T84 Q110 W113 N117 G120 D121 W160 R167
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0061608 nuclear import signal receptor activity
Biological Process
GO:0006606 protein import into nucleus
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4wv6, PDBe:4wv6, PDBj:4wv6
PDBsum4wv6
PubMed25586196
UniProtP52292|IMA1_HUMAN Importin subunit alpha-1 (Gene Name=KPNA2)

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