Structure of PDB 4wnd Chain A Binding Site BS01

Receptor Information
>4wnd Chain A (length=329) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MEASCLELALEGERLCKSGDCRAGVSFFEAAVQVGTEDLKTLSAIYSQLG
NAYFYLHDYAKALEYHHHDLTLARTIGDQLGEAKASGNLGNTLKVLGNFD
EAIVCCQRHLDISRELNDKVGEARALYNLGNVYHAKGKSFGCFPEEVRDA
LQAAVDFYEENLSLVTALGDRAAQGRAFGNLGNTHYLLGNFRDAVIAHEQ
RLLIAKEFGDKAAERRAYSNLGNAYIFLGEFETASEYYKKTLLLARQLKD
RAVEAQSCYSLGNTYTLLQDYEKAIDYHLKHLAIAQELNDRIGEGRACWS
LGNAYTALGNHDQAMHFAEKHLEISREVG
Ligand information
>4wnd Chain B (length=26) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
QLLHSDHMEMEPETMETKSVTDYFSK
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB4wnd Structural basis for the recognition of the scaffold protein Frmpd4/Preso1 by the TPR domain of the adaptor protein LGN
Resolution1.5 Å
Binding residue
(original residue number in PDB)		L18 L22 E25 K52 A56 S59 Q60 N63 D81 G93 K96 N100 N103 H121 R136 Y139 H146 R196 N200 N203 L207 R221 R235 R236 N240 Q276 Y279 N283 T286 L287 R316 W319
Binding residue
(residue number reindexed from 1)		L6 L10 E13 K40 A44 S47 Q48 N51 D69 G81 K84 N88 N91 H109 R124 Y127 H134 R176 N180 N183 L187 R201 R215 R216 N220 Q256 Y259 N263 T266 L267 R296 W299
Enzymatic activity
Enzyme Commision number ?
External links
PDB RCSB:4wnd, PDBe:4wnd, PDBj:4wnd
PDBsum4wnd
PubMed25664792
UniProtP81274|GPSM2_HUMAN G-protein-signaling modulator 2 (Gene Name=GPSM2)

[Back to BioLiP]