Structure of PDB 4whh Chain A Binding Site BS01
Receptor Information
>4whh Chain A (length=210) Species:
9606
(Homo sapiens) [
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HLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYG
LGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSL
MKKITLLKYFRNYMSEHLLKAGANILPYLRTWFRTRSAIILHLSNGSVQI
NFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRY
ARTMVDKLLS
Ligand information
>4whh Chain B (length=4) Species:
32630
(synthetic construct) [
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tHST
Receptor-Ligand Complex Structure
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PDB
4whh
A new class of peptidomimetics targeting the polo-box domain of polo-like kinase 1.
Resolution
1.9 Å
Binding residue
(original residue number in PDB)
K413 W414 V415 D416 Y421 Y481 Y485 L490 L491 H538 K540
Binding residue
(residue number reindexed from 1)
K41 W42 V43 D44 Y49 Y109 Y113 L118 L119 H156 K158
Enzymatic activity
Enzyme Commision number
2.7.11.21
: polo kinase.
External links
PDB
RCSB:4whh
,
PDBe:4whh
,
PDBj:4whh
PDBsum
4whh
PubMed
25347203
UniProt
P53350
|PLK1_HUMAN Serine/threonine-protein kinase PLK1 (Gene Name=PLK1)
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