Structure of PDB 4wfh Chain A Binding Site BS01

Receptor Information
>4wfh Chain A (length=253) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RSTTLLALLALVLLYLVSGALVFRALEQPHEQQAQRELGEVREKFLRAHP
CVSDQELGLLIKEVADALGGGADPETSHSAWDLGSAFFFSGTIITTIGYG
NVALRTDAGRLFCIFYALVGIPLFGILLAGVGDRLGSSLRHGIGHIEAIF
LKWHVPPELVRVLSAMLFLLIGCLLFVLTPTFVFCYMEDWSKLEAIYFVI
VTLTTVGFGDYVAGADPRQDSPAYQPLVWFWILLGLAYFASVLTTIGNWL
RVV
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain4wfh Chain A Residue 305 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4wfh Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel.
Resolution3.01 Å
Binding residue
(original residue number in PDB)		S112 D115 S118 D249
Binding residue
(residue number reindexed from 1)		S79 D82 S85 D216
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005267 potassium channel activity
Biological Process
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4wfh, PDBe:4wfh, PDBj:4wfh
PDBsum4wfh
PubMed25471887
UniProtQ9NYG8|KCNK4_HUMAN Potassium channel subfamily K member 4 (Gene Name=KCNK4)

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