Structure of PDB 4w50 Chain A Binding Site BS01
Receptor Information
>4w50 Chain A (length=177) Species:
9606
(Homo sapiens) [
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GNEVTLLDSRSVQGELGWIASPLEGGWEEVSIMDEKNTPIRTYQVCNVME
PSQNNWLRTDWITREGAQRVYIEIKFTLRDCNSLPGVMGTCKETFNLYYY
ESDNDKERFIRENQFVKIDTIAADESFTQVDIGDRIMKLNTEIRDVGPLS
KKGFYLAFQDVGACIALVSVRVFYKKA
Ligand information
>4w50 Chain E (length=12) Species:
32630
(synthetic construct) [
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APYCVYRGSWSC
Receptor-Ligand Complex Structure
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PDB
4w50
Development and Structural Analysis of a Nanomolar Cyclic Peptide Antagonist for the EphA4 Receptor.
Resolution
2.42 Å
Binding residue
(original residue number in PDB)
I59 Q71 C73 T104 R106 P112 R162 M164 C191
Binding residue
(residue number reindexed from 1)
I32 Q44 C46 T77 R79 P85 R135 M137 C164
Enzymatic activity
Enzyme Commision number
2.7.10.1
: receptor protein-tyrosine kinase.
External links
PDB
RCSB:4w50
,
PDBe:4w50
,
PDBj:4w50
PDBsum
4w50
PubMed
25268696
UniProt
P54764
|EPHA4_HUMAN Ephrin type-A receptor 4 (Gene Name=EPHA4)
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