Structure of PDB 4v2w Chain A Binding Site BS01
Receptor Information
>4v2w Chain A (length=348) Species:
9606
(Homo sapiens) [
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TLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPR
ASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIANSDKY
CTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTI
LDLVEKESGITIEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPK
SWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIP
FDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLC
SCRKDMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFL
Ligand information
>4v2w Chain C (length=4) Species:
9606
(Homo sapiens) [
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ARKS
Receptor-Ligand Complex Structure
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PDB
4v2w
Studies on the Catalytic Domains of Multiple Jmjc Oxygenases Using Peptide Substrates.
Resolution
1.81 Å
Binding residue
(original residue number in PDB)
D135 E169 G170 Y175 Y177 K241 S288 N290 V313
Binding residue
(residue number reindexed from 1)
D129 E163 G164 Y169 Y171 K235 S282 N284 V307
Enzymatic activity
Catalytic site (original residue number in PDB)
G170 Y177 H188 E190 H276 S288
Catalytic site (residue number reindexed from 1)
G164 Y171 H182 E184 H270 S282
Enzyme Commision number
1.14.11.66
: [histone H3]-trimethyl-L-lysine(9) demethylase.
1.14.11.69
: [histone H3]-trimethyl-L-lysine(36) demethylase.
External links
PDB
RCSB:4v2w
,
PDBe:4v2w
,
PDBj:4v2w
PDBsum
4v2w
PubMed
25625844
UniProt
O75164
|KDM4A_HUMAN Lysine-specific demethylase 4A (Gene Name=KDM4A)
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