Structure of PDB 4v2v Chain A Binding Site BS01
Receptor Information
>4v2v Chain A (length=353) Species:
9606
(Homo sapiens) [
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SESETLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKE
WKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIAN
SDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGR
LRTILDLVEKESGITIEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHF
GEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKK
YGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQ
AVLCSCRKDMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAE
FLK
Ligand information
>4v2v Chain C (length=5) Species:
9606
(Homo sapiens) [
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ARKSA
Receptor-Ligand Complex Structure
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PDB
4v2v
Studies on the Catalytic Domains of Multiple Jmjc Oxygenases Using Peptide Substrates.
Resolution
2.0 Å
Binding residue
(original residue number in PDB)
D135 N137 E169 G170 Y175 Y177 K241 S288 T289 N290 D311
Binding residue
(residue number reindexed from 1)
D133 N135 E167 G168 Y173 Y175 K239 S286 T287 N288 D309
Enzymatic activity
Catalytic site (original residue number in PDB)
G170 Y177 H188 E190 H276 S288
Catalytic site (residue number reindexed from 1)
G168 Y175 H186 E188 H274 S286
Enzyme Commision number
1.14.11.66
: [histone H3]-trimethyl-L-lysine(9) demethylase.
1.14.11.69
: [histone H3]-trimethyl-L-lysine(36) demethylase.
External links
PDB
RCSB:4v2v
,
PDBe:4v2v
,
PDBj:4v2v
PDBsum
4v2v
PubMed
25625844
UniProt
O75164
|KDM4A_HUMAN Lysine-specific demethylase 4A (Gene Name=KDM4A)
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