Structure of PDB 4ux8 Chain A Binding Site BS01

Receptor Information
>4ux8 Chain A (length=448) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LYFSRDAYWEKLYVDQAAGTPLLYVHALRDAPEEVPSFRLGQHLYGTYRT
RLHENNWIRIQEDTGLLYLQRSLDHSSWEKLSVRNRGFPLLTVYLKVFLS
PCQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENRPPGTF
HQFRLLPVQFLCPQISVAYRLLEGEGLPFRSAPDSLEVSTRWALDREQRE
KYELVAVCTVHREEVVMVPFPVTVYDEDDSAPTFPAGVDTASAVVEFKRK
EDTVVATLRVFDADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNET
SVQANGSFVRATVHDYRLVLNRNLSISENRTMQLAVLVNDSLHLPSTYSL
SVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSGANCSTLGVVTSAED
TSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEGSY
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain4ux8 Chain A Residue 1603 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4ux8 Ret Recognition of Gdnf-Gfralpha1 Ligand by a Composite Binding Site Promotes Membrane-Proximal Self-Association.
Resolution24.0 Å
Binding residue
(original residue number in PDB)		E178 D264 E265 D267 D302
Binding residue
(residue number reindexed from 1)		E143 D226 E227 D229 D264
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
Biological Process
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4ux8, PDBe:4ux8, PDBj:4ux8
PDBsum4ux8
PubMed25242331
UniProtP07949|RET_HUMAN Proto-oncogene tyrosine-protein kinase receptor Ret (Gene Name=RET)

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