Structure of PDB 4uuv Chain A Binding Site BS01

Receptor Information

>4uuv Chain A (length=96) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GALQLWQFLVALLDDPTNAHFIAWTGRGMEFKLIEPEEVARLWGIQKNRP
AMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCEPDALFSMAFPD

Ligand information

>4uuv Chain B (length=10) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

accggaagtg

Receptor-Ligand Complex Structure

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PDB	4uuv Structures of the Ets Domains of Transcription Factors Etv1, Etv4, Etv5 and Fev: Determinants of DNA Binding and Redox Regulation by Disulfide Bond Formation.
Resolution	2.8 Å
Binding residue (original residue number in PDB)	Y392 R397 R400 Y403 K410 R415 Y416
Binding residue (residue number reindexed from 1)	Y54 R59 R62 Y65 K72 R77 Y78

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003700	DNA-binding transcription factor activity
GO:0043565	sequence-specific DNA binding

	Biological Process
GO:0006355	regulation of DNA-templated transcription
GO:0006357	regulation of transcription by RNA polymerase II

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Molecular Function

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Biological Process

External links

PDB	RCSB:4uuv, PDBe:4uuv, PDBj:4uuv
PDBsum	4uuv
PubMed	25866208
UniProt	P43268\|ETV4_HUMAN ETS translocation variant 4 (Gene Name=ETV4)

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