Structure of PDB 4u90 Chain A Binding Site BS01

Receptor Information
>4u90 Chain A (length=411) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SPFPLTSMDKAFITVLEMTPVLGTEIINYRDGMGRVLAQDVYAKDNLPPF
PASVKDGYAVRAADGPGDRFIIGESQAGEQPTQTVMPGQVMRVTTGAPIP
CGADAVVQVEDTELIRESDDGTEELEVRILVQARPGQDIRPIGHDIKRGE
CVLAKGTHMGPSEIGLLATVGVTEVEVNKFPVVAVMSTGNELLNPEDDLL
PGKIRDSNRSTLLATIQEHGYPTINLGIVGDNPDDLLNALNEGISRADVI
ITSGGVDYLKQVLDIDLHAQIHFGRVFMKPGLPTTFATLDIDGVRKIIFA
LPGNPVSAVVTCNLFVVPALRKMQGILDPRPTIIKARLSCDVKLDPRPEY
HRCILTWHHQEPLPWAQSTGNQSRLMSMRSANGLLMLPPKTEQYVELHKG
EVVDVMVIGRL
Ligand information
Receptor-Ligand Complex Structure
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PDB4u90 Design and Synthesis of High-Affinity Dimeric Inhibitors Targeting the Interactions between Gephyrin and Inhibitory Neurotransmitter Receptors.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		M326 D327 F330 R653 P654 I656 Y673 M711 P713 V727 D729
Binding residue
(residue number reindexed from 1)		M8 D9 F12 R330 P331 I333 Y350 M386 P388 V402 D404
Enzymatic activity
Enzyme Commision number 2.10.1.1: molybdopterin molybdotransferase.
2.7.7.75: molybdopterin adenylyltransferase.
Gene Ontology
Biological Process
GO:0006777 Mo-molybdopterin cofactor biosynthetic process
GO:0032324 molybdopterin cofactor biosynthetic process

View graph for
Biological Process
External links
PDB RCSB:4u90, PDBe:4u90, PDBj:4u90
PDBsum4u90
PubMed25413248
UniProtQ03555|GEPH_RAT Gephyrin (Gene Name=Gphn)

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