Structure of PDB 4u4w Chain A Binding Site BS01

Receptor Information
>4u4w Chain A (length=438) Species: 511145 (Escherichia coli str. K-12 substr. MG1655) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TGAVITDWRPEDPAFWQQRGQRIASRNLWISVPCLLLAFCVWMLFSAVAV
NLPKVGFNFTTDQLFMLTALPSVSGALLRVPYSFMVPIFGGRRWTAFSTG
ILIIPCVWLGFAVQDTSTPYSVFIIISLLCGFAGANFASSMANISFFFPK
QKQGGALGLNGGLGNMGVSVMQLVAPLVVSLSIFAVFGSQGVKQPDGTEL
YLANASWIWVPFLAIFTIAAWFGMNDLATSKAKRGHLWIMSLLYLATFGS
FIGFSAGFAMLSKTQFPDVQILQYAFFGPFIGALARSAGGALSDRLGGTR
VTLVNFILMAIFSGLLFLTLPTDGQGGSFMAFFAVFLALFLTAGLGSGST
FQMISVIFRKLTMDRVKAEGGSDERAMREAATDTAAALGFISAIGAIGGF
FIPKAFGSSLALTGSPVGAMKVFLIFYIACVVITWAVY
Ligand information
Ligand IDNO3
InChIInChI=1S/NO3/c2-1(3)4/q-1
InChIKeyNHNBFGGVMKEFGY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341		[O-][N+]([O-])=O
OpenEye OEToolkits 1.5.0[N+](=O)([O-])[O-]
FormulaN O3
NameNITRATE ION
ChEMBLCHEMBL186200
DrugBankDB14049
ZINC
PDB chain4u4w Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4u4w Structural basis for dynamic mechanism of nitrate/nitrite antiport by NarK
Resolution2.4 Å
Binding residue
(original residue number in PDB)		F49 R89 F147 Y263 F267 R305
Binding residue
(residue number reindexed from 1)		F39 R79 F137 Y244 F248 R286
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005452 solute:inorganic anion antiporter activity
GO:0015112 nitrate transmembrane transporter activity
GO:0015113 nitrite transmembrane transporter activity
GO:0022857 transmembrane transporter activity
Biological Process
GO:0015706 nitrate transmembrane transport
GO:0015707 nitrite transport
GO:0042128 nitrate assimilation
GO:0043602 nitrate catabolic process
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:4u4w, PDBe:4u4w, PDBj:4u4w
PDBsum4u4w
PubMed25959928
UniProtP10903|NARK_ECOLI Nitrate/nitrite antiporter NarK (Gene Name=narK)

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