Structure of PDB 4tzu Chain A Binding Site BS01

Receptor Information

>4tzu Chain A (length=90) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

TSLCCKQCQETEITTKNEIFSLSETLTVYKASNLNLIGRPSTVHSWFPGY
AWTIAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLP

Ligand information

InChI=1S/Zn/q+2

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Zn

Name

ZINC ION

PDB chain

4tzu Chain A Residue 503 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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PDB	4tzu Structural Basis for Responsiveness to Thalidomide-Analog Drugs Defined by the Crystal Structure of the Human Cereblon:DDB1:Lenalidomide Complex
Resolution	2.0 Å
Binding residue (original residue number in PDB)	C325 C328 C393 C396
Binding residue (residue number reindexed from 1)	C5 C8 C57 C60
Annotation score	4

Enzymatic activity

Enzyme Commision number

External links

PDB	RCSB:4tzu, PDBe:4tzu, PDBj:4tzu
PDBsum	4tzu
PubMed
UniProt	Q8C7D2\|CRBN_MOUSE Protein cereblon (Gene Name=Crbn)

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