Structure of PDB 4tz6 Chain A Binding Site BS01

Receptor Information
>4tz6 Chain A (length=504) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SKLIHVPKEEVTLDSLLEEGVLDKEIHKAITRMEFPGLTPVQQKTIKPIL
SSEDHDVIARAKTGTGKTFAFLIPIFQHLINTKFDSQYMVKAVIVAPTRD
LALQIEAEVKKIHDMNYGLKKYACVSLVGGTDFRAAMNKMNKLRPNIVIA
TPGRLIDVLEKYSNKFFRFVDYKVLDEADRLLEIGFRDDLETISGILNEK
NSKSADNIKTLLFSATLDDKVQKLANNIMNKKECLFLDTVDKNEPEAHER
IDQSVVISEKFANSIFAAVEHIKKQIKERDSNYKAIIFAPTVKFTSFLCS
ILKNEFKKDLPILEFHGKITQNKRTSLVKRFKKDESGILVCTDVGARGMD
FPNVHEVLQIGVPSELANYIHRIGRTARSGKEGSSVLFICKDELPFVREL
EDAKNIVIAKQEKYEPSEEIKSEVLEAVTEEPEDISDIVISLISSYRSCI
KEYRFSERRILPEIASTYGVLLNDPQLKIPVSRRFLDKLGLSRSPIGKAM
FEIR
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4tz6 Molecular insights into RNA and DNA helicase evolution from the determinants of specificity for a DEAD-box RNA helicase.
Resolution3.209 Å
Binding residue
(original residue number in PDB)		P188 T189 R190 G220 G221 T242 G244 R245 D248 R271 F277 T382 V383 H407 G408 R415 T433 S535 S536
Binding residue
(residue number reindexed from 1)		P97 T98 R99 G129 G130 T151 G153 R154 D157 R180 F186 T291 V292 H316 G317 R324 T342 S444 S445
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:4tz6, PDBe:4tz6, PDBj:4tz6
PDBsum4tz6
PubMed25497230
UniProtP15424|MS116_YEAST ATP-dependent RNA helicase MSS116, mitochondrial (Gene Name=MSS116)

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