Structure of PDB 4twe Chain A Binding Site BS01

Receptor Information
>4twe Chain A (length=706) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LAPQDLDLEILETVMGQLDAHRIRENLRELSREPHLASSPRDEDLVQLLL
QRWKDPESGLDSAEASTYEVLLSFPSQEQPNVVDIVGPTGGIIHSCHRTE
ENVTGEQGGPDVVQPYAAYAPSGTPQGLLVYANRGAEEDFKELQTQGIKL
EGTIALTRYGGVGRGAKAVNAAKHGVAGVLVYTDPADINDGLSSPDETFP
NSWYLPPSGVERGSYYEYFGDPLTPYLPAVPSSFRVDLANVSGFPPIPTQ
PIGFQDARDLLCNLNGTLAPATWQGALGCHYRLGPGFRPDGDFPADSQVN
VSVYNRLELRNSSNVLGIIRGAVEPDRYVLYGNHRDSWVHGAVDPSSGTA
VLLELSRVLGTLLKKGTWRPRRSIVFASWGAEEFGLIGSTEFTEEFFNKL
QERTVAYINVDISVFANATLRVQGTPPVQSVVFSATKEIRSPGPGDLSIY
DNWIRYFNRSSPVYGLVPSLGSLGAGSDYAPFVHFLGISSMDIAYTYDRS
KTSARIYPTYHTAFDTFDYVDKFLDPGFSSHQAVARTAGSVILRLSDSFF
LPLKVSDYSETLRSFLQAAQQDLGALLEQHSISLGPLVTAVEKFEAEAAA
LGQRISTLQKGSPDPLQVRMLNDQLMLLERTFLNPRAFPEERYYSHVLWA
PRTGSVVTFPGLSNACSRARDTASGSEAWAEVQRQLSIVVTALEGAAATL
RPVADL
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain4twe Chain A Residue 801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4twe Structural and biochemical characterization of a novel aminopeptidase from human intestine.
Resolution1.75 Å
Binding residue
(original residue number in PDB)		D378 E417 H545
Binding residue
(residue number reindexed from 1)		D344 E383 H511
Annotation score1
Enzymatic activity
Enzyme Commision number 3.4.11.-
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0004180 carboxypeptidase activity
GO:0005509 calcium ion binding
GO:0008233 peptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0043171 peptide catabolic process
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016324 apical plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4twe, PDBe:4twe, PDBj:4twe
PDBsum4twe
PubMed25752612
UniProtQ9UQQ1|NALDL_HUMAN Aminopeptidase NAALADL1 (Gene Name=NAALADL1)

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