Structure of PDB 4tpj Chain A Binding Site BS01

Receptor Information

>4tpj Chain A (length=445) Species: 211586 (Shewanella oneidensis MR-1)

VSKTHSFMTVSLIELWERFGYYGMQALIVYFMVQRLGFDDSRANLVWSAC
AALIYVSPAIGGWVGDKILGTKRTMLLGAGILSVGYALMTVPTENTWFMF
SALGVIVVGNGLFKPNAGNLVRKIYESKIDSAFTIYYMAVNVGSTFSMLL
TPWIKDYVNAQYGNEFGWHAAFAVCCVGILVGLGNYALMHKSLANYGSEP
DTRPVNKKSLAIVLALAALSVVASAIILEYEDVARVFVYAAGVAVLGIIA
ALILTVQTVFFFIFYQQMSTSLALFALRNVDWDFQVFGTHLWTWSPAQFQ
ALNPIWIMVLSPVLAWIAAKFALGFAVVAIGFFIYGFAGQFAVNGKTSSW
VMIWGYASYSLGELLVSGLGLAMIARYMMGAYFVASGISQYLGGVVANFA
SVPQDLVDPLQTLPVYTNLFNKLGVAAVVCTIIALAVLPLMRRLT

Ligand information

>4tpj Chain E (length=3) Species: 211586 (Shewanella oneidensis MR-1)

AAA

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4tpj Selectivity mechanism of a bacterial homolog of the human drug-peptide transporters PepT1 and PepT2.
• Resolution: 3.201 Å
• Binding residue (original residue number in PDB): R25 Y29 S154 Y291 N329
• Binding residue (residue number reindexed from 1): R18 Y22 S144 Y265 N303

Gene Ontology

Molecular Function

• GO:0015333 peptide:proton symporter activity
• GO:0022857 transmembrane transporter activity
• GO:0042802 identical protein binding
• GO:0042937 tripeptide transmembrane transporter activity
• GO:0071916 dipeptide transmembrane transporter activity
• GO:1904680 peptide transmembrane transporter activity

Biological Process

• GO:0015833 peptide transport
• GO:0035442 dipeptide transmembrane transport
• GO:0042939 tripeptide transport
• GO:0055085 transmembrane transport
• GO:1902600 proton transmembrane transport

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:4tpj, PDBe:4tpj, PDBj:4tpj
• PDBsum: 4tpj
• PubMed: 25064511
• UniProt: Q8EHE6