Structure of PDB 4tn7 Chain A Binding Site BS01
Receptor Information
>4tn7 Chain A (length=329) Species:
10090
(Mus musculus) [
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RTFDLEEKLQTNKYNANFVTFMEGKDFNVEYIQRGGLRDPLIFKNSDGLG
IKMPDPDFTVNDVKMCVGSRRMVDVMDVNTQKGIEMTMAQWTRYYETPEE
EREKLYNVISLEFSHTRLENMVQRPSTVDFIDWVDNMWPRHLKESQTEST
NAILEMQYPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHIHQGGKVFWLIP
PTAHNLELYENWLLSGKQGDIFLGDRVSDCQRIELKQGYTFVIPSGWIHA
VYTPTDTLVFGGNFLHSFNIPMQLKIYSIEDRTRVPNKFRYPFYYEMCWY
VLERYVYCITNRSHLTKDFQKESLSMDME
Ligand information
>4tn7 Chain E (length=10) Species:
9606
(Homo sapiens) [
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APATGGVKKP
Receptor-Ligand Complex Structure
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PDB
4tn7
A molecular threading mechanism underlies Jumonji lysine demethylase KDM2A regulation of methylated H3K36.
Resolution
2.2 Å
Binding residue
(original residue number in PDB)
M111 Q116 I144 S145 N186 A187 I188 Y199 N298 K323 F324 R325
Binding residue
(residue number reindexed from 1)
M76 Q81 I109 S110 N151 A152 I153 Y164 N263 K288 F289 R290
Enzymatic activity
Enzyme Commision number
1.14.11.27
: [histone H3]-dimethyl-L-lysine(36) demethylase.
External links
PDB
RCSB:4tn7
,
PDBe:4tn7
,
PDBj:4tn7
PDBsum
4tn7
PubMed
25128496
UniProt
P59997
|KDM2A_MOUSE Lysine-specific demethylase 2A (Gene Name=Kdm2a)
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