Structure of PDB 4tll Chain A Binding Site BS01

Receptor Information
>4tll Chain A (length=767) Species: 8355 (Xenopus laevis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DPKIVNIGAVLSTKKHEQIFREAVNQANFFHFTRKIQLNATSVTHRPNAI
QMALSVCEDLISSQVYAILVSHPPAPTDHLTPTPISYTAGFYRIPVIGLT
TRMSIYSDKSIHLSFLRTVPPYSHQALVWFEMMRLFNWNHVILIVSDDHE
GRAAQKKLETLLEEKESKADKVLQFEPGTKNLTALLLEAKELEARVIILS
ASEDDATAVYKSAAMLDMTGAGYVWLVGEREISGSALRYAPDGIIGLQLI
NGKNESAHISDAVAVVAQAIHELFEMEQITDPPRGCVGNTNIWKTGPLFK
RVLMSSKYPDGVTGRIEFNEDGDRKFAQYSIMNLQNRKLVQVGIFDGSYI
IQNDRKIIWPGGETERPQGYQMSTRLKIVTIHQEPFVYVRPTTSDGTCRE
EYTINGDPIKKVICNGPDETIPGRPTVPQCCYGFCVDLLIKLAREMDFTY
EVHLVADGKFGTQERVNNSNAAAWNGMMGELLSGQADMIVAPLTINNERA
QYIEFSKPFKYQGLTILVKKEIPRSTLDSFMQPFQSTLWLLVGLSVHVVA
VMLYLLDRFLSSAMWFSWRVLLSFSARILGMVWAGFAMIIVASYTANLAA
FLVLRRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTMY
RHMEKHNYESAAEAIQAVRDNKLHAFIWDSAVLEFEASQKCDLVTTGELF
FRSGFGIGMRKDSPWKQEVSLNILKSHENGFMEELDKTWVRYQECDAGGI
VAGIFLIFIEIAYKSRA
Ligand information
Ligand ID1AC
InChIInChI=1S/C4H7NO2/c5-4(1-2-4)3(6)7/h1-2,5H2,(H,6,7)
InChIKeyPAJPWUMXBYXFCZ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341NC1(CC1)C(O)=O
OpenEye OEToolkits 1.5.0C1CC1(C(=O)O)N
ACDLabs 10.04O=C(O)C1(N)CC1
FormulaC4 H7 N O2
Name1-AMINOCYCLOPROPANECARBOXYLIC ACID
ChEMBLCHEMBL265325
DrugBankDB02085
ZINCZINC000000895536
PDB chain4tll Chain A Residue 904 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4tll NMDA receptor structures reveal subunit arrangement and pore architecture.
Resolution3.59 Å
Binding residue
(original residue number in PDB)		F482 L515 T516 R521 S678 W721 D722
Binding residue
(residue number reindexed from 1)		F460 L493 T494 R499 S635 W678 D679
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004972 NMDA glutamate receptor activity
GO:0005216 monoatomic ion channel activity
GO:0005515 protein binding
GO:0015276 ligand-gated monoatomic ion channel activity
GO:0015280 ligand-gated sodium channel activity
GO:0022849 glutamate-gated calcium ion channel activity
GO:0038023 signaling receptor activity
GO:0046872 metal ion binding
Biological Process
GO:0006811 monoatomic ion transport
GO:0007268 chemical synaptic transmission
GO:0010043 response to zinc ion
GO:0019722 calcium-mediated signaling
GO:0034220 monoatomic ion transmembrane transport
GO:0035235 ionotropic glutamate receptor signaling pathway
GO:0035725 sodium ion transmembrane transport
GO:0042391 regulation of membrane potential
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0017146 NMDA selective glutamate receptor complex
GO:0043005 neuron projection
GO:0045202 synapse
GO:0045211 postsynaptic membrane
GO:0098839 postsynaptic density membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4tll, PDBe:4tll, PDBj:4tll
PDBsum4tll
PubMed25008524
UniProtA0A1L8F5J9|NMDZ1_XENLA Glutamate receptor ionotropic, NMDA 1 (Gene Name=grin1)

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