Structure of PDB 4srn Chain A Binding Site BS01

Receptor Information
>4srn Chain A (length=113) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHES
LADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTT
QANKHIIVACEGN
Ligand information
Receptor-Ligand Complex Structure
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PDB4srn Structural changes that accompany the reduced catalytic efficiency of two semisynthetic ribonuclease analogs.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		A4 F8 T45 C58 Y73 I81 K104 H105 I106 I107 V108 A109 C110 E111 G112 N113
Binding residue
(residue number reindexed from 1)		A4 F8 T45 C58 Y73 I81 K104 H105 I106 I107 V108 A109 C110 E111 G112 N113
Enzymatic activity
Catalytic site (original residue number in PDB) H12 K41
Catalytic site (residue number reindexed from 1) H12 K41
Enzyme Commision number 4.6.1.18: pancreatic ribonuclease.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0004519 endonuclease activity
GO:0004522 ribonuclease A activity
GO:0004540 RNA nuclease activity
GO:0005515 protein binding
GO:0016829 lyase activity
Biological Process
GO:0050830 defense response to Gram-positive bacterium
Cellular Component
GO:0005576 extracellular region

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Biological Process
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Cellular Component
External links
PDB RCSB:4srn, PDBe:4srn, PDBj:4srn
PDBsum4srn
PubMed1730593
UniProtP61823|RNAS1_BOVIN Ribonuclease pancreatic (Gene Name=RNASE1)

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