Structure of PDB 4s3n Chain A Binding Site BS01

Receptor Information
>4s3n Chain A (length=343) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MDLYSTPAAALDRFVARKLQPRKEFVEKARRALGALAAALRERPRVLKTV
KGGSSGRGTALKGGCDSELVIFLDCFKSYVDQRARRAEILSEMRASLESW
WQNPVPGLRLTFPEQSVPGALQFRLTSVDLEDWMDVSLVPAFNVLGQVKP
KPQVYSTLLNSGCQGGEHAACFTELRRNFVNIRPAKLKNLILLVKHWYHQ
VCLQETLPPVYALELLTIFAWEQGCKKDAFSLAEGLRTVLGLIQQHQHLC
VFWTVNYGFEDPAVGQFLQRQLKRPRPVILDPADPTWDLGNGAAWHWDLL
AQEAASCYDHPCFLRGMGDPVQSWKGPGLPRAGCSGLGHPIQL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4s3n Structural mechanism of sensing long dsRNA via a noncatalytic domain in human oligoadenylate synthetase 3.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		K23 R41 E42 R53 V54 L55 N193 K200
Binding residue
(residue number reindexed from 1)		K23 R41 E42 R45 V46 L47 N181 K188
Enzymatic activity
Enzyme Commision number 2.7.7.84: 2'-5' oligoadenylate synthase.
Gene Ontology
Molecular Function
GO:0016779 nucleotidyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:4s3n, PDBe:4s3n, PDBj:4s3n
PDBsum4s3n
PubMed25775560
UniProtQ9Y6K5|OAS3_HUMAN 2'-5'-oligoadenylate synthase 3 (Gene Name=OAS3)

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