Structure of PDB 4s0g Chain A Binding Site BS01

Receptor Information
>4s0g Chain A (length=279) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DTLEGSMAQLKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNLDKNRYK
DVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQ
FWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSE
DCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPAHGVPDDSSDFLEFVNY
VRSLRVDSEPVLVHSSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKM
RDQRAMMVQTSSQYKFVCEAILRVYEEGL
Ligand information
Receptor-Ligand Complex Structure
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PDB4s0g Substrate specificity and plasticity of FERM-containing protein tyrosine phosphatases.
Resolution1.723 Å
Binding residue
(original residue number in PDB)		Y676 K677 D678 H812 S842 S843 A844 I846 G847 R848
Binding residue
(residue number reindexed from 1)		Y49 K50 D51 H185 S215 S216 A217 I219 G220 R221
Enzymatic activity
Catalytic site (original residue number in PDB) A811 S842 R848 T849 Q886
Catalytic site (residue number reindexed from 1) A184 S215 R221 T222 Q259
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4s0g, PDBe:4s0g, PDBj:4s0g
PDBsum4s0g
PubMed25728925
UniProtP26045|PTN3_HUMAN Tyrosine-protein phosphatase non-receptor type 3 (Gene Name=PTPN3)

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