Structure of PDB 4rzr Chain A Binding Site BS01

Receptor Information

>4rzr Chain A (length=342) Species: 273057 (Saccharolobus solfataricus P2)

MIVLFVDFDYFYAQVEEVLNPSLKGKPVVVCVFSGRFEDSGAVATANYEA
RKFGVKAGIPIVEAKKILPNAVYLPMRKEVYQQVSSRIMNLLREYSEKIE
IASIDEAYLDISDKVRDYREAYNLGLEIKNKILEKEKITVTVGISKNKVF
AKIAADMAKPNGIKVIDDEEVKRLIRELDIADVPGIGNITAEKLKKLGIN
KLVDTLSIEFDKLKGMIGEAKAKYLISLARDEYNEPIRTRVRKSIGRIVT
MKRNSRNLEEIKPYLFRAIEESYYKLDKRIPKAIHVVAVTEDLDIVSRGR
TFPHGISKETAYSESVKLLQKILEEDERKIRRIGVRFSKFIE

Ligand information

>4rzr Chain B (length=14)

ggactggtattggg

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4rzr Mechanistic Basis for the Bypass of a Bulky DNA Adduct Catalyzed by a Y-Family DNA Polymerase.
• Resolution: 2.2 Å
• Binding residue (original residue number in PDB): V32 S34 A42 A44 G58 G218 A220 R240 R242 K243 S244 G246 R247 I248 T250 R331 R336
• Binding residue (residue number reindexed from 1): V32 S34 A42 A44 G58 G218 A220 R240 R242 K243 S244 G246 R247 I248 T250 R331 R336

Enzymatic activity

• Enzyme Commision number: 2.7.7.7: DNA-directed DNA polymerase.

Gene Ontology

Molecular Function

• GO:0000287 magnesium ion binding
• GO:0003677 DNA binding
• GO:0003684 damaged DNA binding
• GO:0003887 DNA-directed DNA polymerase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006260 DNA replication
• GO:0006261 DNA-templated DNA replication
• GO:0006281 DNA repair
• GO:0006974 DNA damage response
• GO:0042276 error-prone translesion synthesis

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:4rzr, PDBe:4rzr, PDBj:4rzr
• PDBsum: 4rzr
• PubMed: 26327169
• UniProt: Q97W02|DPO4_SACS2 DNA polymerase IV (Gene Name=dbh)