Structure of PDB 4rwd Chain A Binding Site BS01

Receptor Information

>4rwd Chain A (length=401) Species: 562,9606

ADLEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKATPPKLED
KSPDSPEMKDFRHGFDILVGQIDDALKLANEGKVKEAQAAAEQLKTTRNA
YIQKYLGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKT
ATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNM
FTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVP
IMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVC
YGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVI
VWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQL
C

Ligand information

>4rwd Chain H (length=4) Species: 32630 (synthetic construct)

YGFF

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4rwd Structural basis for bifunctional peptide recognition at human delta-opioid receptor.
• Resolution: 2.7 Å
• Binding residue (original residue number in PDB): L125 D128 Y129 M132 M199 V217 I277 V281 I304
• Binding residue (residue number reindexed from 1): L193 D196 Y197 M200 M267 V285 I345 V349 I372

Gene Ontology

Molecular Function

• GO:0004930 G protein-coupled receptor activity
• GO:0004985 G protein-coupled opioid receptor activity
• GO:0005506 iron ion binding
• GO:0009055 electron transfer activity
• GO:0020037 heme binding
• GO:0038046 G protein-coupled enkephalin receptor activity
• GO:0046872 metal ion binding

Biological Process

• GO:0007186 G protein-coupled receptor signaling pathway
• GO:0022900 electron transport chain

Cellular Component

• GO:0016020 membrane
• GO:0042597 periplasmic space

External links

• PDB: RCSB:4rwd, PDBe:4rwd, PDBj:4rwd
• PDBsum: 4rwd
• PubMed: 25686086
• UniProt: P0ABE7|C562_ECOLX Soluble cytochrome b562 (Gene Name=cybC);
  P41143|OPRD_HUMAN Delta-type opioid receptor (Gene Name=OPRD1)