Structure of PDB 4rvf Chain A Binding Site BS01

Receptor Information
>4rvf Chain A (length=418) Species: 41951 (Streptomyces argillaceus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TARAVTTCRMCGAQDWQEVVDFGPVPLADSFLEPAASYDDEPRYPLAVVS
CRSCRLMSLTHVVDPEVLYRTYPYTTSDSETIKKHMGHVVAVCVERFGIP
EGSFVLEIGSNTGSQLKAFQNAGMRTLGIDPARNIAAVANERGIETLPEF
FSVDTAALVKKTHGTPQLVLGRHVFAHIDDVSAVAEGVRDLLGPDSLFAI
EVPYLVDMLERNEFDTIYHEHLSYIGVGSLVALFRRHGLRVVDVERLAVH
GGSILVFVGLDEGTRATAPVVEELIALEKERGLYEDATYERFARHVAEIT
AELTSMVRSLRAEGKRIAGYGAPAKGNTLLNVCGLTADDLEFCCDTTEFK
QGLVLPGTHIPVRSPEYAKTQAIDYYLLLAWNYGEEILAKEGPFLADGGR
FILPNPRPSIVPPGEHHH
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain4rvf Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4rvf Structural Insight into MtmC, a Bifunctional Ketoreductase-Methyltransferase Involved in the Assembly of the Mithramycin Trisaccharide Chain.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		C13 C16 C56 C59
Binding residue
(residue number reindexed from 1)		C8 C11 C51 C54
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4rvf, PDBe:4rvf, PDBj:4rvf
PDBsum4rvf
PubMed25587924
UniProtQ194Q4

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