Structure of PDB 4rno Chain A Binding Site BS01

Receptor Information
>4rno Chain A (length=425) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIAV
SYEARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASVEVM
EIMSRFAVIERASIDEAYVDLTSAVQERLQKLGQPISADLLPSTYIEGLP
QGPTVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRAAIER
ETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIRKIR
SLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMCRGIE
HDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERLTKDR
NDNDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTVIKNC
NTSGIQTEWSPLTMLFLCATKFSAS
Ligand information
Receptor-Ligand Complex Structure
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PDB4rno Structural and Kinetic Analysis of Nucleoside Triphosphate Incorporation Opposite an Abasic Site by Human Translesion DNA Polymerase eta.
Resolution2.82 Å
Binding residue
(original residue number in PDB)		Q38 Y39 W42 G46 I47 I48 R61 S62 W64 K86 K293 P316 K317 T318 I319 G320 C321 S322 K323 N324 P326 G327
Binding residue
(residue number reindexed from 1)		Q38 Y39 W42 G46 I47 I48 R61 S62 W64 K86 K287 P310 K311 T312 I313 G314 C315 S316 K317 N318 P320 G321
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:4rno, PDBe:4rno, PDBj:4rno
PDBsum4rno
PubMed25666608
UniProtQ9Y253|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)

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